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Contraindication for Injectable Methylprednisolone Products Containing Lactose (Solu-Medrone 40mg/vial) in Patients with Cow’s Milk Allergy

Injectable methylprednisolone products containing lactose are authorised for use in a range of different indications including the treatment of symptoms of severe allergic reactions and other inflammatory conditions. In Ireland, Solu-Medrone Powder and Solvent for Solution for Injection or Concentrate for Solution for Infusion 40mg/vial is the only authorised injectable methylprednisolone-containing product formulated with lactose, and may contain trace amounts of milk proteins.   An EU review was initiated following reports of serious allergic reactions, including bronchospasm and anaphylaxis, in patients allergic to cow’s milk treated with injectable methylprednisolone products that contain lactose. The majority of patients were younger than…