Glossary

GLOSSARY

Key to Symbols

N ............. preparation which may be dispensed once only unless specific instructions are issued to the contrary.
M ............. preparation which in the absence of specific instructions to the contrary may be dispensed for six months only, and at such intervals over the six month period following its issue as the dispenser considers appropriate, having regard to dosage rate.
O ......... GMS reimbursable.
T ........... High Tech Scheme reimbursable.
= ........... product that can be substituted by another product on the list of interchangeable medicines.
L ........... product controlled under the Misuse of Drugs Act.
K .......... preparation available over the counter in pharmacy without a prescription.
U ... agent for diagnostic use only.
1 ... nutritional.
Y ....... available in pharmacy without prescription but under the supervision of the pharmacist.
J ..... consultant use only or therapy should be initiated under consultant supervision.
+ ............. product subject to additional monitoring.
.............. The trade price is given for all non-reimbursed products (including most OTC products). The reimbursement price is given for nutritional products. The Price To Wholesalers (PTW) is given for all other PCRS (GMS) reimbursed products, products on the High-Tech scheme and hospital-only products, unless otherwise stated.
D Contraindications: Conditions where the product should not be given. Hypersensitivity to a drug (and/or excipients) or its class is assumed to be a contraindication in all entries.
B Special precautions: Conditions where special attention is required, or tests are to be performed. Serious side effects that need attention.
C Drug interactions: Drugs which may affect, or be affected by, the product if prescribed together.
A Adverse drug reactions: Most frequently reported side effects.
2 ........ This medicinal product is permitted for use in sport.
5 ........ This medicinal product contains substance(s) prohibited for use in sport. Athletes seeking to use this product are required to adhere to Sport Ireland's TUE Policy.
6 ... This medicinal product contains substance(s) prohibited for use in sport, in men only. Male Athletes seeking to use this product are required to adhere to Sport Ireland's TUE Policy.
0 ... This medicinal product contains substance(s) prohibited for use in sport during the competition period only. Athletes seeking to use this product in-competition are required to adhere to Sport Ireland's TUE Policy.
3 ...... This medicinal product contains substance(s) prohibited for use in specific sports only (as listed in WADA Prohibited List 2018). Athletes seeking to use this product in these specific sports are required to adhere to Sport Ireland's TUE Policy.
9 ..... This medicinal product contains formoterol, salbutamol or salmeterol.
• Formoterol is permitted when used by inhalation to a maximum delivered dose of 54μg over 24 hours.
• Salbutamol is permitted when used by inhalation to a maximum of 1600μg over 24 hours in divided doses, not to exceed 800μg over 12 hours, starting from any dose.
• Salmeterol is permitted when used by inhalation to a maximum dose of 200μg over 24 hours.
Athletes requesting to use formoterol by inhalation at delivered doses >54μg over 24 hours, salbutamol by inhalation at doses >1600μg over 24 hours or >800μg over 12 hours, or salmeterol by inhalation at doses >200μg over 24 hours must adhere to the TUE Policy paying particular attention to the requirements of a medical file.
Note: A Turbohaler device labelled as containing 6μg of formoterol results in the delivery of 4.5μg of formoterol.
Medical File
All Therapeutic Use Exemption (TUE) applications MUST be accompanied by a medical file reflecting current best medical practice to include:
1) A complete medical history
2) Copies of all relevant examinations and clinical notes (for example, if a clinic visit is referenced in a letter or summary, a copy of the clinical notes taken during the visit must be included)
3) Copies of laboratory results/reports, and imaging studies
4) Exact name, speciality, address (including telephone, e-mail, fax) of examining physician
For asthma TUE applications, the medical file should also specifically include:
5) A comprehensive report of the clinical examination with specific focus on the respiratory system
6) A report of spirometry with the measure of the Forced Expiratory Volume in 1 second (FEV1)
7) If airway obstruction is present, the spirometry will be repeated after inhalation of a short acting β-2 agonist to demonstrate the reversibility of bronchoconstriction
8) In the absence of reversible airway obstruction, a bronchial provocation test is required to establish the presence of airway hyperresponsiveness

Key to Abbreviations

5-HT = serotonin
AA = amino acid
ACE = angiotensin converting enzyme
admin. = administration/ administer
AED = anti-epileptic drug
ALT = alanine aminotransferase
AMD = age-related macular degeneration
AST = aspartate aminotransferase
BCRP = breast cancer resistant protein
BP = blood pressure
BPH = benign prostatic hyperplasia
Ca++ = calcium
CAD = coronary artery disease
Cal-Pk = calendar pack
cap. = capsule
cc = creatinine clearance
CF = cystic fibrosis
CHF = congestive heart failure
CI = chloride
CNS = central nervous system
COMT = catechol-O-methyl transferase
COX = cyclooxygenase
CVD = cardiovascular disease
diHCL = dihydrochloride
DVT = deep vein thrombosis
ECT = electroconvulsive therapy
ent-ctd = enteric-coated
film-ctd = film coated
G6PD = glucose-6-phosphate dehydrogenase
GI = gastro-intestinal
GORD = gastroesophageal reflux disease
Hb = hemoglobin
HCI = hydrochloride
HCTZ = hydrochlorothiazide
HF = heart failure
IBD = inflammatory bowel disease
Ig = immunoglobulin
IM = intramuscular
incl. = including
inj. = injection
IV = intravenous
IOP = intraocular pressure
K+ = potassium
LDH = lactate dehydrogenase
LVEF = left ventricular ejection fraction
MAOI = monoamine oxidase inhibitor
MI = myocardial infarction
MRP = multidrug resistance-associated protein
NA = noradrenaline
Na+ = sodium
NRTI = nucleoside reverse
transcriptase
inhibitor
NSAID = non steroidal anti-inflammatory drug
OAT = organic anion transporter
OCT = organic cation transporter
PD = Parkinson's disease
PE = pulmonary embolism
P-gp = P-glycoprotein
PPI = proton pump inhibitor
rcv = rubber capped vial
resp. = respectively
RO = reflux oesophagitis
RTI = respiratory tract infection
SC = subcutaneous
SLE = Systemic Lupus Erythematosus
CVD = cardiovascular disease
sln = solution
SPC = summary of product characteristics
SSRI = selective serotonin reuptake inhibitor
sug-ctd = sugar-coated
suppl. = supplement
tab. = tablet
TCA = tricyclic antidepressant
TIA = transient ischaemic attack
UC = ulcerative colitis
ULN = upper limit of
normal
UTI = urinary tract
infection
WBC = white blood cell